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Dr. Renée H. Martin

PhD (British Columbia), FCCMG
Professor Emerita
Department of Medical Genetics, University of Calgary
Tel: (250) 473-7002
Fax: (403) 270-2211
Email:

Research Interests
Dr. Martin has investigated the causes of chromosome abnormalities in humans, with an emphasis on human sperm chromosome abnormalities.  Recent research has been on the increased risk of sperm chromosomal abnormalities in cancer patients treated by chemotherapy, meiotic abnormalities in infertile patients and the link between meiotic recombination and chromosome abnormalities in sperm.

Dr. Martin enjoyed continuous funding from the Medical Research Council / Canadian Institutes of Health Research from 1983-2009, and has more than 200 refereed publications.  She was President of the Canadian Fertility and Andrology Society in 1992-1993, and President of the Canadian College of Medical Geneticists in 1997-1998.  Dr. Martin held the Canada Research Chair in Genetics from 2002-2009 and was recently elected a fellow of the Canadian Academy of Health Sciences and a fellow of the Royal Society of Canada.  She is now Professor Emerita and is enjoying life on a vineyard in the Okanagan.

Publications

Tempest HG, Ko E, Chan P, Robaire B, Rademaker A, Martin RH. 2008 Sperm aneuploidy frequencies analysed before and after chemotherapy in testicular cancer and Hodgkin’s lymphoma patients. Human Reproduction 23:251-258

 

Martin RH. 2008 Meiotic errors in human oogenesis and spermatogenesis. Reproductive BioMedicine Online 16:523-531

 

Sun F, Mikhaail-Philips M, Oliver-Bonet M, Ko E, Rademaker A, Turek P, Martin RH. 2008 The relationship between meiotic recombination in human spermatocytes and aneuploidy in sperm. Human Reproduction 23:1691-1697

 

Martin RH. 2008 Cytogenetic determinants of male infertility. Human Reproduction Update 14(4):379-390

 

Sun F, Mikhaail-Philips M, Oliver-Bonet M, Ko E, Rademaker A, Turek P, Martin RH. 2008 Reduced recombination on the XY bivalent is correlated with an increased incidence of sex chromosome aneuploidy in men with non-obstructive azoospermia. Molecular Human Reproduction 14(7):399-404

 

Lian J, Yin Y, Oliver-Bonet M, Liehr T, Ko E, Turek P, Sun F, Martin RH. 2008 Variation in crossover interference levels on individual chromosomes from human males.  Human Molecular Genetics 17:2583-2594. Selected for cover illustration.

 

Tempest HG, Ko E, Rademaker A, Chan P, Robaire B, Martin RH. 2009 Intra- and inter-individual variations in sperm aneuploidy frequencies in normal men. Fertility and Sterility 91:185-192

 

Ko E, Martin RH. 2009 Immunofluorescence analysis of human spermatocytes. Methods in Molecular Biology 558:401-418.  

Tempest HG, Martin RH. 2009 Meiotic recombination and errors during spermatogenesis. In: Reproductive Endocrinology and Infertility: Clinical and Laboratory Aspects. Eds. CM Peterson and D Carrell, Humana Press (in press)

 

Tempest H, Martin RH. 2009 Cytogenetic risks in chromosomally normal infertile men.  Current Opinion in Obstetrics and Gynecology, ed. A Arici, 21: 223-227.

 

Research Funding

 

CIHR

“Analysis of early meiosis and the etiology of chromosomal abnormalities in human sperm” 2004-2009

“Canada Research Chair in Genetics” 2002-2009

“Post-Doctoral Fellowship for Helen Tempest” 2006-2008