|
Dr. Paul E. Mains
Professor,
Departments of Biochemistry & Molecular Biology/Medical Genetics
University of Calgary, Health Sciences Centre
Tel: (403) 220-7997 Fax: (403) 270-0737
Email:
Research Interests
We use the nematode roundworm Caenorhabditis elegans to study animal embryogenesis. Our work focuses on two genetic networks that enable ubiquitous cellular structures, the actin and microtubule-based cytoskeletons, to carry out specific processes critical to embryonic development. One project studies genes required for the actn-mediated transformation of the spherical embryo into the long, thin vermiform larva. Our other work involves genes that modify the tubulin cytoskeleton to form the specialized spindle required for female meiosis.
Publications
Lu, C., and Mains, P.E. (2007). The C. elegans anaphase promoting complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis. Dev. Bil. 302: 438-447.
Johnson, J.F.A., Lu, C., Raharjo, E., McNally, K., McNally, F.J. and Mains, P.E. (2009) Changing levels of the ubiquitin ligase substrate adaptor protein MEL-26 regulates MEI-1/katanin microtubule severing activity at both meiosis and mitosis. Develop. Biol. in press.
Han, X., Gomes, J.E., Birmingham, C.L., Pintard, L., Sugimoto, A. and Mains, P.E. (2009) The role of protein phosphatase 4 in regulating microtubule severing in C. elegans.Genetics, 181: 933–943.
Luo, J., Shah, S., Riabowol, K. and Mains, P.E. (2009) The Caenorhabditis elegans ing-3 gene regulates ionizing radiation-induced germ cell apoptosis in a p53-associated pathway. Genetics, 181: 473-482.
Research Funding
CIHR
|
 |
|
|
