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Dr. Floyd F. Snyder Research Interests
My research interests are in inherited metabolic disease. A recent emphasis is on the application of metabolomic principles to the analysis of complex metabolite data sets obtained from patients with known disorders. These analyses have the potential to reveal previously unrecognized metabolic relationships which may have utility as biomarkers in defining disease progression or provide direction with regard to improved therapy.
We are continuing work on the mitochondrial protein import mutation in DNAJC19 associated with dilated cardiomyopathy and ataxia. The competency of oxidative metabolism in mutant cells is being probed using heavy isotope metabolic loading and tandem MS analyses and metabolomic assessment.
A longstanding interest in nucleotide metabolism has led to the development of antiparasitics in which bacterial and protozoan pathogen specific pathways are exploited for the activation of otherwise inert purine nucleoside and base analogs.
Publications
Davey, KM, Parboosingh, JS, McLeod, DR, Chan, A, Casey, R, Ferreira, P, Snyder, FF, Bridge, PJ, Bernier, FP. Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition. J Med Genet 2006; 43(5): 385-393
Snyder FF, Carter, RJ, Fung, E, Hodges, SD, Mantik, KB. Application of metabolomic principles to disorders of nucleotide metabolism reveals new metabolic perturbations
Nucleosides, Nucleotides and Nucleic Acids (November 2007, in press)
Research Funding
CIHR
Alberta Children’s Hospital Foundation
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BSc (Calgary), MSc (McMaster), PhD (Alberta), FCCMG
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