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Dr. R. Brian Lowry
Research Interests
My interests are those of prevalence trends of congenital anomalies in Alberta using the database of the Alberta Congenital Anomalies Surveillance System (ACASS). We participated in a seven province study of the Effects of Folic Acid Fortification on Neural Tube Defects. Results were published (see below). The observed reduction rate in the post fortification period was 46%. ACASS is also a member of the International Clearinghouse for Birth Defects Surveillance and Research and contributes and participates in collaborative research. Our data was one of 16 Registries which was published in the British Medical Journal 2006; 332:423-424 confirming the remarkable worldwide increase in prevalence rates of gastroschisis. We are also participating in research in craniofacial disorders, very rare defects and orofacial defects.
I also study the natural history of rare congenital syndromes and the delineation of new syndromes.
ACASS published a new annual report (2007) of the Alberta Congenital Anomalies Surveillance System (7th) 1980-2005. Obtainable on the website http://www.health.alberta.ca/resources/publications/ACASS 2007.pdf or in print form.
ACASS and/or Dept. members are actively involved in the organization of the Canadian Congenital Anomalies Surveillance Network (CCASN). Barbara Sibbald, Ruth Kohut and Brian Lowry are members of the Advisory Group and various Working Groups. Tanya Bedard is also a Working Group member. The Network is a subgroup of the Canadian Perinatal Surveillance System and the Public Health Agency of Canada and has it’s own website and newsletter. http://www.phac-aspc.gc.ca/ccasn-rcsac/index.html
Publications
Lowry RB.Congenital Anomalies Surveillance in Canada. Can J Publ Health. 2008;99,483-485
Godwin KA,Sibbald B,Bedard T,Kuzeljevic B,Lowry RB,Arbour L.Changes in the Frequencies of Select Congenital Anomalies since the onset of Folic Acid Fortification in a Canadian Birth Defect Registry.Can J Publ Health.2008;99,271-275
Lowry RB,Johnson CY,Gagnon F,Little J.Segregation Analysis of Cleft Lip with or without Cleft Palate in the First Nations(Amerindian) People of British Columbia and Review of Isolated Cleft Palate Etiologies.Birth Defects Research A.2009;85,568-573
Ferrier RA,Lowry RB,Lemire EG,Stoeber GP,Howard J,Parboosingh JS.Father-to-Son Transmission of an X-linked Gene:A Case of Paternal Sex Chromosome Heterodisomy.Am J Med Genet.2009;149A,2871-2873
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MD, DSc, FRCPC (Pediatrics & Medical Genetics), FCCMG
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